HORDB

General Information

ID: hor002470
Uniprot ID: NA
Protein name: Proctolin
Gene name: NA
Organism: Blaberus craniifer
Family: NA
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: NA
GO MF: NA
GO BP: NA
GO CC: NA

Sequence Information

Sequence: RYLPT
Length: 5
Propeptide: NA
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Caused dose dependent contractions of Blaberus fore- and hindgut
Mechanism: induced contractions are likely mediated via a phospholipase C linked to a heptahelical receptor bound to heterotrimeric G-proteins
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: Foregut:1.29nM;hindgut:1.1nM
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002470_AF2.pdb

hor002470_ESM.pdb

Physical Information

Mass:	72028	Formula:	C30H48N8O8
Absent amino acids:	ACDEFGHIKMNQSVW	Common amino acids:	LPRTY
pI:	9.35	Basic residues:	1
Polar residues:	2	Hydrophobic residues:	1
Hydrophobicity:	-86	Boman Index:	-1271
Half-Life:	1 hour	Half-Life Yeast:	2 min
Half-Life E.Coli:	2 min	Aliphatic Index	78
Instability Index:	3144	Extinction Coefficient cystines:	1490
Absorbance 280nm:	372.5

Literature

PubMed ID: 9880067
Title: Pharmacological Studies of Proctolin Receptors on Foregut and Hindgut of Blaberus Craniifer